Mhv 33702. SARS-CoV-2 belongs to the Betacoronavirus genus, containing the mouse hepatitis virus (MHV), an extensively studied animal coronavirus. Mhv 33702

 
 SARS-CoV-2 belongs to the Betacoronavirus genus, containing the mouse hepatitis virus (MHV), an extensively studied animal coronavirusMhv 33702  Brian Edwards-Tiekert, e-mail bedwardstiek@wesleyan

State of the art fitness center and heated pool/spa will keep you active and healthy. Neurotropic mouse hepatitis virus (MHV) infection in mice causes meningoencephalitis, myelitis, and demyelination, with relative axonal preservation. SARS-CoV-2 belongs to the Betacoronavirus genus, containing the mouse hepatitis virus (MHV), an extensively studied animal coronavirus. V. Earns interest. The structures generated were in agreement with previous characterizations of SL1 through SL4 and two recently. (727) 362-0032. This right angle MHV to MHV adapter allows for easier connections in tight spaces. Midscale Suburban property. RSA59 and RSMHV2 are isogenic except for the spike gene, which encodes an envelope glycoprotein that mediates many biological properties of. Source: Comparative Medicine, Volume 53, Number 2, April 2003, pp. 336. 1006/viro. mil. Background Coronaviruses such as severe acute respiratory syndrome (SARS) coronavirus (SCoV) and mouse hepatitis virus A59 (MHV-A59) have evolved strategies to disable the innate immune system for productive replication and spread of infection. MHV. Treatment with strictinin (100 μM), but not theacrine, completely eliminated MHV infection, as indicated by a pronounced reduction in plaque formation, nucleocapsid. Whereas MHV-A59 produces acute meningitis, encephalitis, hepatitis, and chronic demyelination, a closely related strain, MHV-2, produces only acute. me - Go to the ID. Español $ USD United States. The aim of this work was to amplify and diversify the autoimmune response restricted to FAH through the use of the exogenous adjuvant. Although murine coronaviruses naturally infect only mice, several virus variants derived from persistently infected murine cell cultures have an extended host range. ∙ 610 Mount Oak Ave NE #734, ST PETERSBURG, FL 33702 ∙ $239,000 ∙ MLS# U8173273 ∙ Enjoy watching manatee, dolphin and beautiful herons from your back patio o. When you complete the Contact Us form and select Submit, the information on that form. 4444. single family home with a list price of $439000. Get Directions. With features like large closets, some with patios. 1 Miles from Saint Petersburg. Mouse hepatitis virus (MHV), the coronavirus of the mouse (mus musculus), is one of the most important viral pathogens in contemporary laboratory mouse colonies. 772 Sq. Neonatal mice suffer high mortality when the vi­1999 Nov 25;264 (2):398-409. 3 North Broad Street. [3] Belonging to the subgenus Embecovirus, [4] murine coronavirus strains are enterotropic or polytropic. Background: Mouse hepatitis virus is probably the most important pathogen of laboratory mice. This finding was revealed by using mouse strains with two different allelic forms of the MHV receptor, Ceacam1a and. In a February 3, 2012, email, Mr. 1445 62nd Ave N, ST PETERSBURG, FL 33702. 25% APR with terms ranging from 1 month minimum to 60 months maximum. Infection of susceptible strains of mice with strain MHV-3 results in severe hepatitis caused, in part, by overexpression of prothrombinase [2]. Please note that all FAQs that begin with VA come from your VA health record. Silver Lake Mobile Home Resort All Ages Community 4000 24th Street North, Saint Petersburg, FL 33714 45 people like this park. Locations. Email Agent. Our practice employs a holistic approach to care for people struggling with addiction, anxiety, insomnia, inattention, fatigue, low mood, stress, and depression. Dendritic cells (DCs) are key cells in the initiation of innate and adaptive immune responses, and infection of these cells could potentially contribute to a dysregulated immune response; consistent with this, recent. LaBrosse to Teri P. Hilton Mandalay Hotel (Sedona Hotel) H-0268. ID. Federal government websites often end in . 8794. Appointments Keep track of your upcoming VA medical appointments and get email reminders. Condo for Sale in 33702, FL: Gorgeous 55+ Adult Community 2 Bedroom (2nd bedroom is an enclosed air conditioned patio with a closet. Hillandale Road VA Clinic. 4444 to make the account available in your “Transfer To” drop-down. Whether buying, selling or renting, our tools and resources make it easy. We found 78 active listings for mobile & manufactured homes. Health Records View, print, or download a copy of your VA medical record information, or enter your. The SARS outbreak in 2002–2003 served as a grim reminder of these viruses' potential to cross the species. In the last few months, { { listingSoldCount }} of those Arizona manufactured homes have been sold. Since the cellular receptors for MHV, mmCGM1 and mmCGM2, have recently been identified as members of. There are 260 apartments for rent in 33702 zip code. Taken together, these studies suggested that MHV-1 produced a mild SARS-like disease in BALB/cJ mice, a mild but significant liver injury, but the. 3390 Gandy Blvd N Lot 10, is a mobile home, built in 1979, with 2 beds and 2 bath, at 1,000 sqft. With the recent surge in the development of genetically engineered mutant. Access to 118,000+ ATMs. Mouse hepatitis virus (MHV)-infected cells contain full-length and subgenomic-length positive- and negative-strand RNAs. FAQs. Veterans can schedule appointments online, refill prescriptions, view their health records, and send Secure Messages to their team using My HealtheVet. Mouse hepatitis virus (MHV) is a coronavirus that causes infection of the CNS (Marten et al. We are pleased to offer our citizens, businesses and visitors online access to permitting, inspection scheduling, fee payments and other services, 24 hours a day, seven days a week. Petersburg. Murine hepatitis virus (MHV) is a non-human pathogen betacoronavirus that is evolutionarily and structurally related to the human pathogenic viruses SARS-CoV, MERS-CoV, and SARS-CoV-2. Verified. Average 3. R. 3 bds; 3 ba; 2,196 sqft - House for sale. Mouse hepatitis virus type 1 (MHV-1) is a group 2 coronavirus capable of causing severe morbidity and mortality in highly susceptible C3H/HeJ mice. Pasternack’s PE9266 MHV male to MHV female right angle adapter is part of our full line of RF components available for . 702 Highland Ave, New Martinsville, WV 26155 is currently not for sale. bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution. Therefore, it is used as a model for viral hepatitis,. The inactivation rate to MHV-A59 coronavirus was up to 99. The 4 bedroom condo at 1440 89th Ave N, Saint Petersburg, FL 33702 is comparable and priced for sale at $735,000. Preferred Date* Mon 20 Tue 21 Wed 22 Request a Tour Email View Homes In This Community View On Map Like 2001 83rd Ave N LOT 5145, Saint Petersburg, FL 33702. Your rebuild cost buys value and a no-shortcut factory specification remanufactured pump. 4444. Learn More. Europe PMC is an archive of life sciences journal literature. Ft. 1 bed. Enterotropic strains include mouse hepatitis virus (MHV) strains D, Y, RI, and DVIM, whereas polytropic strains, such as JHM and A59, primarily cause. North, St Petersburg, FL 33714 ~2. My HealtheVet (MHV). This well maintained, beautifully landscaped 5-star community is located in the heart of Largo, just minutes from the pristine Gulf Beaches. 702 Highland Ave, New Martinsville WV, is a Single Family home that contains 1570 sq ft and was built in 2002. 1,152 Sq Ft. With. The known receptors for MHV are all members of the carcinoembryonic antigen family. 919-383-6107. Hotel has 3 floors. These variants replicated poorly in baby hamster kidney (BHK) and swine testicular (ST) cells. View estimate history. H. The parental WT MHV-A59 (termed MHV-WT) and all mutant viruses were generated using reverse genetics and were subjected to deep sequencing to validate the genotypes. While HCoV-OC43 is a closer mimetic of SARS-CoV-2 than MHV, the MHV has been used for animal disease models in many virological and clinical studies [ 16 ], acting as a model organism for studying coronaviruses [ 17 ]. St. Like. Virol. Buy: $11,900. Top Amenities. To investigate membrane alterations and to characterize the RC of mouse hepatitis virus (MHV), we performed biochemical and ultrastructural studies using MHV-infected cells. Community Owner Tools. $135,900. Zip Code 33702 Map. Table 2. Contact Mouser (USA) (800) 346-6873 | Feedback. 2001 83rd Avenue North, Saint Petersburg, FL 33702. 1 Bath. As the first loop computations were performed for gluon scattering in the helicity basis [7, 8], it became apparent that (relative) simplicity of amplitudes could extend to the loop level. View home features, photos, park info and more. Neurotropic recombinant strain of Mouse Hepatitis Virus, RSA59, induces meningo-encephalitis, myelitis and demyelination following intracranial inoculation. Coronaviruses are a family of large positive-sense RNA viruses that are responsible for a wide range of important veterinary and human diseases. 2001 83rd Avenue North, Saint Petersburg, FL 33702. Earns interest. The ends of the cDNAs were engineered with unique junctions and assembled with only the adjacent. 1. 500 101st Ave N, St Petersburg, FL 33702. 1 fig. This postal code encompasses addresses in the city of Saint Petersburg, FL. Properties sold in 33702 Recently sold homes in 33702 had a median listing home price of $239,950. Conference: MHV '23: 2nd Mile-High Video Conference Denver CO USA May 7 - 10, 2023. Ft. Petersburg, FL, 33702; and Prehired, LLC (0436), 8 The Green, Suite B, Dover, DE. Personal Tellers: 8:00 AM - 8:00 PM. . With the ultimate aim of studying mucosal immunity to MHV we have cloned the genes encoding the structural proteins of MHV strain A59 (MHV-A59) into the E3 region of a human. SD (also termed MHV-4) develop fatal acute encephalitis with a 50% mortality after inoculation with 1 plaque forming unit (pfu) []. The origin and function of the subgenomic negative-strand RNAs is controversial. Barthold Synonyms. gov - Access the Login. MHV strains A59 and JHMV both cause acute and chronic encephalomyelitis and demyelination in susceptible strains. For sale. $62 - $451. Property type. 77306°N 82. J Virol. N15m3 contains an alanine substitution in the catalytic histidine (H262A) residue of nsp15, which was previously shown to inactivate endoribonuclease activity ( 17 , 25 ). View home features, photos, park info and more. A suspicious death, an upscale spiritual retreat, and a quartet of suspects with a motive for murder. Neither MHV antigen nor lesions were found in control mice. You may make one-time or recurring transfers between your own MHV accounts by clicking Make a Transfer within the full Online Banking website or tap Transfers within the MHV Mobile Banking App. 33781 Homes for Sale $322,222. The SARS outbreak in 2002–2003 served as a grim reminder of these viruses' potential to cross the species. Nearby homes similar to 12077 Gandy Blvd N #332 have recently sold between $245K to $849K at an average of $280 per square foot. This Murine Hepatitis Virus A59 nsp9 Antibody (2C6. 1. 3390 Gandy Blvd LOT 96, Saint Petersburg, FL 33702. MHV strain A59 is an extensively studied group II coronavirus , that causes enteritis, hepatitis, and central nervous system demyelination in susceptible mice , . (a) Cleared lysate from MHV-infected LR7 cells (Ext) was centrifuged at 15,000 × g for 10 min to obtain a pellet. Petersburg. It can also contaminate cell cultures and transplantable tumors and be introduced into This well maintained, beautifully landscaped 5-star community is located in the heart of Largo, just minutes from the pristine Gulf Beaches. The number of people in their late 20s to early 40s is extremely large while the number of middle aged adults is large. Proc Natl Acad Sci U S A. This product is stable for several weeks at 4C as an undiluted liquid. MLS# U8157758. 1. COLDWELL BANKER REALTY. Mouse hepatitis virus (MHV)-induced murine neuroinflammation serves as a model to study acute meningoencephalomyelitis, hepatitis, and chronic neuroinflammatory demyelination; which mimics certain pathologies of the human neurologic disease, multiple sclerosis (MS). Phone: (845) 336. [Europe PMC free article] [Google Scholar] Williams RK, Jiang GS, Snyder SW, Frana MF, Holmes KV. Mouse hepatitis virus (MHV) infection in immunocompetent mice is typically self limiting, and transmission is short lived. SARS-CoV-2 infected individuals may be asymptomatic or may experience mild,. Care we provide at VA Durham health care. 6 kb in size and exhibits efficient packaging. 1ba. Trending Searches in Saint Petersburg, FL. SOLD JUN 2, 2023 3D WALKTHROUGH. Dendritic cells (DCs) develop from hematopoietic stem cells (HSCs) in a multistep process that begins in the bone marrow. This chapter attempts to provide an overview of the important aspects of mouse hepatitis virus (MHV) experimental biology while emphasizing the virus as a naturally occurring mouse pathogen. 4444. 655) Wesleyan University Juggling Collective. Mouse hepatitis virus (MHV) utilizes a mouse biliary glycoprotein (Bgp) as a receptor. ORF36 specifically binds to the activated for. Browse real estate in 33702, FL. 3rd Floor, Plot No: 5 Amstor Building Technopark Phase 1 Thiruvananthapuram Kerala, India +91. May 8-10, 2023, Grand Hyatt Denver, Colorado. My HealtheVet - Contact the My HealtheVet Help Desk at 877-327-0022 or 800-877-8339 (TTY), Monday. Village Green 55+ Resort Community, Saint Petersburg, FL 33702 . Single Family. 33702 real estate & homes for sale. Recent studies have additionally demonstrated that neurotropic MHV strains can also induce axonal loss ( 1, 2 ); direct virus-mediated axonal damage can occur concurrently with and. $89 - $299. 77 acre lot. 1). Since its inception in 2004, MHVillage has grown to become the number one consumer website for the manufactured. Use arrow keys to navigate. Join. The positive-strand mRNAs are arranged in a 3′ coterminal. [PMC free article] [Google Scholar] Gallagher TM, Escarmis C, Buchmeier MJ. 74% to a maximum of 16. 4 days on Zillow. See all 23 apartments and houses for rent in 33702, including cheap, affordable, luxury and pet-friendly rentals. The replication cycle is depicted in Fig. Using an antiserum to the hydrophilic carboxy terminus of this otherwise hydrophobic protein, we found that the E protein was synthesized in infected. $343,000. 4 Home additions 211 Plumbing projects Notable project: (Plumbing permit. Chat with one of our loan advisors to answer any questions you have! Or call us at 845. Search Florida mobile homes for sale or rent. 9360) (+41. General FAQs. 33702 real estate & homes for sale Homes for sale in 33702 have a median listing home price of $245,000. Induction of type I interferons (IFNs), a well-known subset of cytokines with antiviral activity, is triggered by a selection of cellular pattern recognition receptors, including TLRs (Toll-like receptors), RIG-I (retinoic acid-inducible gene I), and. Myd88 and TLRs are associated with the severity of COVID-19. PMID: 34960652. MHV-A59 virions use as a receptor a 110- to 120-kDa glycoprotein (MHVR) in the carcinoembryonic antigen (CEA) family of glycoproteins (G. house located at 602 Mount Key Ave NE #633, ST PETERSBURG, FL 33702 sold for $175,000 on Mar 15, 2023. 9345 2nd St N, Saint Petersburg, FL 33702 is for sale. In this report, we demonstrate that persistent MHV infection rapidly promotes the emergence of host range mutants of MHV which replicate efficiently in normally nonpermissive Chinese hamster ovary (CHO) and human cell lines. com®. It has 1,056 sq. H-0278. Mouse hepatitis virus (MHV), a group 2 coronavirus (CoV), is a positive-strand RNA virus. Double check all the fillable fields to ensure total accuracy. MHV strain A59 (MHV-A59) is both hepatotropic and neurotropic and can infect. Reply STOP to any text message you receive from us to stop receiving messages. Here we evaluated the role of alveolar macrophages (AM) in. For even more variety, explore our Airbnb Categories to. Murine hepatitis virus strain A59 (MHV-A59) was shown to induce pyroptosis, apoptosis, and necroptosis of infected cells, especially in the. Open Now. Here’s how we ensure you get a “like new” product: New/Remanufactured Vacuum Pumps. To determine whether Myd88 or. St. 17Cl-1 fibroblasts were transfected with pLuc-IFN-β for 16 to 18 h and then infected with MHV-A59 at an MOI of 100 or MHV-JHM at an MOI of 10 for 12 h (A) or 24 h (B). Find directions to 33702, browse local businesses, landmarks, get current traffic estimates, road conditions, and more. 1900 Glen Lakes Blvd N, Saint Petersburg, FL 33702. The coronavirus mouse hepatitis virus (MHV) is a positive-stranded RNA virus with a genome of about 32 kb. House for Rent View All Details (727) 564-1473 Check Availability. Antibodies directed against several proteins derived from the gene 1 polyprotein, including the 3C-like protease (3CLpro), the putative polymerase (POL), helicase, and a recently described protein (p22) derived from the C terminus of the open. out of 10. The role of receptor binding in coronavirus entry into host cells is a fundamental question in virology. Mouse hepatitis virus (MHV), a prototype coronavirus, is an important pathogen in laboratory animals (Baker, 2003), and the genetics and. 756 sqft. ft. MHV GROUP | 1,484 followers on LinkedIn. $1,915. Mouse hepatitis virus (MHV) can grow in many murine cell lines such as DBT, L2, and 17CL-1 cells. GENETIC DETERMINANTS OF VIRULENCE FOR THE A59 AND JHM STRAINS OF MOUSE HEPATITIS VIRUS Timothy J. Lake Euclid Homes for Sale. Find a manufactured home today. 2 fig. [PMC free article] [Google Scholar] 6. Our MHV to MHV adapter has a male to female gender configuration. Author summary Coronaviruses recognize many receptors using their envelope-anchored spike protein. 33703 Homes for Sale $441,945. . single family home built in 1978 that was last sold on 06/03/2022. Several viruses have been classified as members of this family, which can be subdivided into three antigenic clusters (3, 28). is the nation’s premier online marketplace for buying and selling manufactured homes with more than 25 million unique visitors. Virus altered host metabolism, metabolic hijacking, has been investigated in diverse kinds of viruses, and particularly, glycolysis is shown to be increased by virus infection []. 33705 Homes for Sale $355,796. coli derived full-length Murine Hepatitis Virus A59 nsp9 protein. Read More. Coronaviruses induce in infected cells the formation of double membrane vesicles, which are the sites of RNA replication. 558,-072. Sold Price. , and a new isolate of mouse hepatitis virus (MHV) designated MHV-G. Lobby / Driveup: 9:00 AM – 5:00 PM, Monday through Friday, and 9:00 AM – 2:00 PM on Saturday. . Petersburg and be amazed at how affordable a resort lifestyle can be! You’ll discover friendly people, luxury amenities and newly remodeled homes from the $40’s. Provide both your previous & new addresses as well as any phone number changes. Top Amenities. Although previous studies indicated that susceptibility. 3390 Gandy Blvd LOT 96, Saint Petersburg, FL 33702. The primary cellular receptor for mouse hepatitis virus (MHV), a murine coronavirus, is MHVR (also referred to as Bgp1a or C-CAM), a transmembrane glycoprotein with four immunoglobulin-like domains in the murine biliary glycoprotein (Bgp) subfamily of the carcinoembryonic antigen (CEA) family. house located at 12702 High Vista St, Victorville, CA 92395. If your contact information has changed, please first send us a secure message by clicking Support then Secure Support . Five prototype strains of mouse hepatitis virus (MHV) -1,-3, -S,- A59 and -JHM were analyzed for their ability to induce interferon (IFN) in seven cell lines of rodent origin. The block to virus infection has been variously attributed to defects in virus receptors or virus spread. St. Browse 0 new and used FL manufactured homes on the nation's premier mobile home marketplace. ID. 0 to 32. Featuring one and two bedroom apartment homes, our. Friday, 4 PM, nice weather on Olin Lawn, poor weather in Freeman Fieldhouse, Science Center Lobby. Search from 48 mobile homes for sale or rent near 33702, FL. Nearby homes similar to 610 Mount Oak Ave NE #734 have recently sold between $123K to $355K at an average of $215 per square foot. One of the most widely used cells is the BHK-R cell line that is. If you’re able, tell your care provider that you’re a Veteran. 3 part number fig. me's Help Center. For sale. Ft. Green, Suite B, Dover, DE 19901; Prehired Accelerator, LLC (7910), 7910 4th St. com 2 HS430, HD300 & SD300 Operator’s Guide Metallurgical High Vaccum Corporation 6708 124th Avenue, Fennville, MI 49408 Toll free: 877-787-9880 Fax: (269) 543-4750 [email protected] channel features Military History ranging from Classical Times up to contemporary conflicts. MHV causes hepatitis and demyelinating. MHV stocks were cultured to a viral titer of ~1. 33782 Homes for Sale $316,233. The majority of infections are subclinical, but can still significantly influence biological responses, thus. Revised Date 08/16/2021 Helpful Tips. 1. Susceptible mice infected intracerebrally with the MHV-JHM variant MHV. In our study, it was demonstrated that the 254 nm ultraviolet-C (UVC) is an efficient method to inactivate a coronavirus, mouse hepatitis virus strain A59 (MHV-A59). , toxoid protein) or multimeric antigen (i. St. This murine virus is used as a common model to study acute and chronic virus-induced demyelination in the central nervous system. 4 bds; 2 ba; 1,769 sqft - House for sale. The common 5′. 3390 Gandy Blvd N Lot 652, is a mobile home, built in 1987, with 1 beds and 1 bath, at 456 sqft. (May 2003) Reed Findley Johnson, B. $15 monthly service fee, waived with $10,000 average daily balance in checking or $25,000 across accounts. From over 1,070 condo rentals to over 1,940 house rentals, we've got you covered. A VA Care Coordinator will help you focus on nutrition and exercise to improve your health. 1,260 Sqft. MHV stocks were cultured to a viral titer of ~1. 2bd. recently sold home located at 102 87th Ave N, Saint Petersburg, FL 33702 that was sold on 09/25/2023 for $810000. Find a manufactured home today. This 2 bed/2 bath home of. of living space, kitchen completely remodeled, both baths remodeled with new step-in showers. m. Availability: 9 Homes for Sale Rental Homes Available Tour this Park. By providing insight to self-awareness, we can begin to change negative thought. 1 bath. About My HealtheVet offers you tips and tools to help you partner with your health care team, so together you may work to manage your health. Synthetic peptides that correspond to E from HCoV-229E, MHV, and IBV exhibit a similar cation-selectivity for MHV and IBV E as for SARS-CoV E. Fax: (845) 765. Welcome to your dream waterfront condo! This charmi. , E. The murine coronavirus mouse hepatitis virus (MHV) can cause a range of illnesses depending on the strain. Holiday Inn Express St. ) and neurological disease following nonlethal hepatitis in semisusceptible C3H mice characterized by meningitis, ependymitis, and. Nearby recently sold homes. Waukegan Office. Cytokines are key regulators that dictate many aspects of innate and adaptive immunity. Movoto gives you access to the most up-to-the-minute real estate information in 33702. Map - South Pinellas. Junction of 26th x 66th St, Chanayetharzan Tsp. Browse real estate in 33702, FL. To characterize a mouse model of coronavirus-induced acute respiratory infection inside a BSL2 facility, 6- to 7-week-old C57BL/6J mice were inoculated via the intranasal route with 10³ PFU of MHV-3 and monitored daily for signs of illness (Fig. What's the housing market like in 33702? (Stellar MLS as Distributed by MLS Grid) Sold: 3 beds, 2 baths, 1196 sq. Transmission: Fecal-oral, direct. 1,445 Sq. 33702 Home for Sale: Beautifully remodeled 2 bed/2 bath home with special attention to detail throughout the home. 636 Mount Piney Ave NE, ST PETERSBURG, FL 33702. 2 Beds • 2 Bath. 2 ba. Upon entry into the cell, the viral genome is transcribed into seven to eight subgenomic mRNAs ranging in size from ∼1. This study aimed to develop a real-time reverse transcription recombinase polymerase amplification (RT-RPA) method for rapid detection of MHV in laboratory mice. 33702 ZIP Code is spread between the coordinates of +27. Mice were killed at intervals up to 18 days after inoculation, and their tissues were examined. Viasat - Fast up to 150 Mbps. (727) 201-1890. The CoV mouse hepatitis virus (MHV), the prototype member and molecular model for the genus, was utilized to study mechanisms of host range expansion. Video WalkthroughThe nucleotide sequence of the cloned full-length MHV-A59 cDNA was found to correspond to the authentic MHV-A59 consensus sequence, with the exception of one change that had been specifically introduced by site-directed mutagenesis for cloning purposes (modification of the EagI site in plasmid pMHe-link) and three silent nucleotide. Ft. Availability: 9 Homes for Sale Rental. Read More. Neurotropic strains of mouse hepatitis virus (MHV) have been used extensively for the study of viral pathogenesis in the central nervous system (CNS), serving as models for human neurological diseases such as multiple sclerosis (MS).